National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. 5. Vitamins and Stroke Prevention: Is a Healthy Diet Good Enough? Find NCBI SARS-CoV-2 literature, sequence, and clinical content: Am J Cardiol 2009;103:393-394. J Clin Lipidol. A shift in the routine prescribing of statin therapy to every-other-day would have important implications. Statins: Practical Considerations - A Review. Some patients decide to stop taking statins, a cholesterol-lowering drug, if they experience side effects. Efficacy and tolerability of once-weekly rosuvastatin in patients with previous statin intolerance. Once-a-week rosuvastatin (2. Epub 2011 Sep 21. 5 to 20 mg) in patients with a previous statin intolerance Am J Cardiol, 103 (3) (2009), pp. A significant difference in the mean percentage change in LDL from baseline for rosuvastatin vs. placebo was identified (12.2% reduction vs. 0.4% reduction, respectively; P = .002). 1. Conclusion: Many patients who could benefit from hydroxymethylglutaryl coenzyme-A reductase inhibitors (statins) are unable to take statins because of myalgias while taking previous statin therapy. 2008 Mar;42(3):341-6. doi: 10.1345/aph.1K604. Statin Use and Cognitive Effects: Not a Brain Drain. Katsiki N, Athyros VG, Karagiannis A, Mikhailidis DP. It is important to recognize that the retrospective observational study reported by Ruisinger was performed in a very small group of patients (n = 50) and was not placebo-controlled.  |  Weekly dosing has the potential to lower costs and increase convenience while maintaining a similar effect on lipids. Am J Cardiovasc Drugs. Be diligent about putting back the nutrients that statins interfere with such as the coenzyme Q10, selenium, and vitamin K2, along with other heart healthy nutrients. Dr. Karpman reports no financial relationship to this field of study. Rosuvastatin 5 and 10 mg/d: a pilot study of the effects in hypercholesterolemic adults unable to tolerate other statins and reach LDL cholesterol goals with nonstatin lipid-lowering therapies. Glueck CJ, Aregawi D, Agloria M, Khalil Q, Winiarska M, Munjal J, Gogineni S, Wang P. Clin Ther. One-year efficacy and safety of rosuvastatin + fenofibric acid combination therapy in patients with mixed dyslipidemia: evaluation of dose response. Backes JM, Venero CV, Gibson CA, Ruisinger JF, Howard PA, Thompson PD, Moriarty PM. Please enable it to take advantage of the complete set of features! J Am Pharm Assoc 2005;45: 503-513. The primary efficacy outcome was the difference in the mean percentage change in LDL from baseline between rosuvastatin and placebo. 3. The once-a-week schedule was tolerated by 74% of the patients with doses ranging from 2.5 to 20 mg once weekly. NLM Is an Even Safer Combined Oral Contraceptive Pill Available? Two 8-week treatment phases consisted of rosuvastatin 5 mg once-weekly or matching placebo, with a dose titration to 10 mg once-weekly if not at LDL goal at week 4. Results: A significant difference in the mean percentage change in LDL from baseline for rosuvastatin … 2006 Jun;28(6):933-42. doi: 10.1016/j.clinthera.2006.06.004. Am J Cardiol 2009;103:393-394. Get the latest public health information from CDC: A prospective trial of once-a-week rosuvastatin dosing in individuals with a history of myalgias on statin therapy achieved a >12% lowering of LDL-C … There are exceptions to taking these nutrients so ask your doctor (yes, the same one that gave you the statin.) In addition, three patients (20%) were able to attain LDL goal on rosuvastatin compared with zero patients (0%) on placebo. Ferdinand KC, Davidson MH, Kelly MT, Setze CM. PLoS Curr. 2013 Dec 4;5:ecurrents.eogt.d21e7f0c58463571bb0d9d3a19b82203. The are several explanations as to why rosuvastatin was so well tolerated in the study including: Lower plasma concentrations from infrequent drug dosing are less likely to cause adverse effects, simply switching to a different statin quite possibly could have helped some patients tolerate the medication, and/or the psychological effects of taking the medication only once a week may have contributed to the improved drug tolerance in this small group of patients who otherwise might have experienced an adverse effect if treated with a daily statin drug. 2004 Sep;26(9):1368-87. doi: 10.1016/j.clinthera.2004.09.005. Comparison of the efficacy and safety of rosuvastatin versus atorvastatin, simvastatin, and pravastatin across doses (STELLAR* trial). The lipid-lowering effects of once-a-week rosuvastatin proved to be statistically significant; however, no attempt was made to determine whether this alternative dosing regimen was capable of reducing cardiovascular events over the course of this relatively short-term study. Jones PH, et al; STELLAR Study Group. Non-traditional dosing of statins in statin-intolerant patients-is it worth a try? Source: Ruisinger JF, et al. Periodic rosuvastatin or atorvastatin dosing arrays (PRADA): patient-centered practice. 2. Background: A new study tracked how they did. The specific dosage used for each patient was based primarily on each patient's prior history of statin use and the severity of the adverse events that they developed. Patients with lipid levels measured 1-3 days and 4-7 days after receiving their last rosuvastatin dose had similar mean LDL-C reductions. This site needs JavaScript to work properly. 393-394 Article Download PDF View Record in Scopus Google Scholar Once-a-week rosuvastatin (2.5 to 20 mg) in patients with a previous statin intolerance. By Harold L. Karpman, MD, FACC, FACP, Clinical Professor of Medicine, UCLA School of Medicine. Effectiveness and tolerability of every-other-day rosuvastatin dosing in patients with prior statin intolerance. Is There a Link Between Miscarriage and Future Cardiovascular Disease? COVID-19 is an emerging, rapidly evolving situation. Two 8-week treatment phases consisted of rosuvastatin 5 mg once-weekly or matching placebo, with a dose titration to 10 mg once-weekly if not at LDL goal at week 4. 2010;10(6):383-400. doi: 10.2165/11204600-000000000-00000. Atorvastatin is a potent antihyperlipidemic but is quite expensive, costing up to $700 for a 1-year supply of 10-mg tablets in retail pharmacies. Synopsis: Once-a-week rosuvastatin therapy was well tolerated in patients with a history of adverse events to one or more statins and led to significantly improved lipoprotein changes. In this randomized, double-blind, placebo-controlled crossover study we enrolled a total of 17 Clement J. Zablocki Veterans Affairs (VA) primary care patients with a diagnosis of hyperlipidemia and a history of myalgias on statin therapy who were not currently on a statin and not at LDL goal. Epub 2008 Feb 19.  |  The once-a-week dosing schedule was well tolerated in this small group of patients with a history of adverse events to 1 or more statin drugs and led to significantly improved lipoprotein levels, but large randomized trials are needed to confirm these findings and determine whether the once-a-week alternative dosing schedule is more desirable than no statin therapy at all for statin-intolerant patients with abnormally elevated serum lipids. Once-a-week rosuvastatin (2.5 to 20 mg) in patients with a previous statin intolerance. Methods: Take once daily. SLCO1B1 Polymorphisms and Statin-Induced Myopathy. doi: 10.1371/currents.eogt.d21e7f0c58463571bb0d9d3a19b82203. Once-a-week rosuvastatin (2. Rosuvastatin once a week was tolerated by 37 (74%) of the 50 study participants, with doses ranging from 2.5 mg to 20 mg a week (mean 10 +/- 4 mg). Efficacy of Patient Aligned Care Team Pharmacist Services in Reaching Diabetes and Hyperlipidemia Treatment Goals. The dosage of atorvastatin needs to be individualized but initially should start at 10-20 mg/day and be guided by the results of cholesterol … Ann Pharmacother 2008; 42:341-346. Alternate day treatment will be less expensive, and non-daily dose of certain statins may reduce the already-low but concerning incidence of musculoskeletal pain and weakness that can be a side effect of statin use.

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