Ethylene glycol is teratogenic, inducing primarily skeletal and external malformations, sometimes at doses less than those that are maternally toxic, with mice being more sensitive than rats. The detailed report by Swor et al. Similarities and differences across these compounds are explained by metabolic pathways. Signal: Warning GHS Hazard Statements H302: Harmful if swallowed [Warning Acute toxicity, oral] Precautionary Statement Codes P264, P270, P301+P312, P330, and P501 (The corresponding statement to each P-code can be found at the GHS Classification page.) After absorption, ethylene glycol is distributed in internal fluids. Ethylene glycol is rapidly absorbed through the gastrointestinal tract, and its vapor or aerosol is absorbed through the respiratory tract. Introduction: Ethylene glycol itself is toxic, but its harmful effects mainly result from the accumulation of its more toxic metabolites. Chris Nickson; Nov 3, 2020; Home CCC. Ethylene glycol is a central nervous system (CNS) depressant that can produce acute effects similar to those of ethanol. Only monoethylene and diethylene glycol show evidence of developmental toxicity. Ethylene Glycol CAS RN: 107-21-1 GHS Classification. above is a valuable contribution, owing particularly to an absence of any previous equine evidence of ethylene glycol toxicity reported in the scientific literature. Ethylene glycol compounds share acute toxicity modes of action. Ethylene glycol is an inexpensive, readily available substance that may be associated with accidental or intentional toxicity. Ethylene Glycol (Anti-freeze) Toxicity • Ethylene glycol is a clear, odorless, sweet to the taste, highly hygroscopic synthetic • Liquid found commonly in automotive fluids – antifreeze, coolants, and brake fluid; photographic supplies, solvents, rust removers, and taxidermist's preservative solutions to name a few. Ethylene Glycol Toxicity. EU REGULATION (EC) No 1272/2008 >. In the liver and kidneys, he undergoes enzymatic metabolism. These CNS effects predominate during the first hours after exposure. OVERVIEW >1 mL/kg or a mouthful in a child is potentially lethal; ethylene glycol itself is relatively non-toxic -> metabolites extremely toxic (glycolate) rate limiting step = alcohol dehydrogenase activity; accumulation of glycolate -> direct cellular toxicity; CLINICAL FEATURES . Signal: Warning GHS Hazard Statements … describe the three stages of ethylene glycol toxicity. Ethylene glycol toxicity Ethylene glycol toxicity Frape, D. L. 2002-10-01 00:00:00 Ethylene glycol toxicity D. L. FRAPE The Priory, Churchyard, Mildenhall, Suffolk IP28 7EE, UK.

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